Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.

@article{Dubois2001EvidenceTF,
  title={Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.},
  author={Claire M Dubois and François Blanchette and M H Laprise and Richard Leduc and Francine Grondin and Nabil G Seidah},
  journal={The American journal of pathology},
  year={2001},
  volume={158 1},
  pages={305-16}
}
Transforming growth factor (TGF)-beta1 plays an essential role in cell growth and differentiation. It is also considered as a gatekeeper of immune homeostasis with gene disruption leading to autoimmune and inflammatory diseases. TGF-beta1 is produced as an inactive precursor polypeptide that can be efficiently secreted but correct proteolytic cleavage is an essential step for its activation. Assessment of the cleavage site has revealed a unique R-H-R-R sequence reminiscent of proprotein… CONTINUE READING

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