Evidence that ferric nitrilotriacetate mediates oxidative stress by down-regulating DT-diaphorase activity: implications for carcinogenesis.

@article{Iqbal1999EvidenceTF,
  title={Evidence that ferric nitrilotriacetate mediates oxidative stress by down-regulating DT-diaphorase activity: implications for carcinogenesis.},
  author={Mohammed Iqbal and Som Datta Sharma and Ayman A. Rahim A. Rahman and P Trikha and Mohammad Athar},
  journal={Cancer letters},
  year={1999},
  volume={141 1-2},
  pages={151-7}
}
Ferric nitrilotriacetate (Fe-NTA) is a known complete renal carcinogen as well as renal and hepatic tumor promoter, which acts by generating oxidative stress in the tissue. However, the mechanism by which it generates this stress is not fully understood. In this study, we show that Fe-NTA down-regulates hepatic and renal quinone reductase (QR) activity dose dependently. The maximum decrease in the activity of QR was observed at 12 h in the liver and 6 h in the kidney following Fe-NTA treatment… CONTINUE READING

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