Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils.

@article{Binet2010EvidenceTE,
  title={Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils.},
  author={François Binet and Sonia Chiasson and Denis Girard},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={391 1},
  pages={18-23}
}
Apoptosis can result from activation of three major pathways: the extrinsic, the intrinsic, and the most recently identified endoplasmic reticulum (ER) stress-mediated pathway. While the two former pathways are known to be operational in human polymorphonuclear neutrophils (PMNs), the existence of the ER stress-mediated pathway, generally involving caspase-4, has never been reported in these cells. Recently, we have documented that arsenic trioxide (ATO) induced apoptosis in human PMNs by a… CONTINUE READING

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