Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep.

@article{Goodman2004EvidenceTD,
  title={Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep.},
  author={Robert L. Goodman and Lique M Coolen and Greg M Anderson and Steven L Hardy and Miro Valent and John M Connors and Maureen E Fitzgerald and Michael N Lehman},
  journal={Endocrinology},
  year={2004},
  volume={145 6},
  pages={2959-67}
}
Endogenous opioid peptides (EOP) mediate progesterone-negative feedback in many species, but the specific EOP systems involved remain unresolved. We first addressed this question in sheep by determining the role of different EOP receptor subtypes in the medial basal hypothalamus (MBH) and preoptic area (POA). Local administration of EOP receptor antagonists to luteal phase ewes indicated that kappa-, but not micro- or delta-, receptors mediate the inhibition of LH secretion in the MBH. In… CONTINUE READING
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