Corpus ID: 35819546

Evidence that dynorphin-(1-13) acts as an agonist on opioid kappa-receptors.

@article{Oka1982EvidenceTD,
  title={Evidence that dynorphin-(1-13) acts as an agonist on opioid kappa-receptors.},
  author={Tetsuo Oka and Kazuko Negishi and Mitsuaki Suda and Aiko Sawa and Masahiko Fujino and Mitsuhiro Wakimasu},
  journal={European journal of pharmacology},
  year={1982},
  volume={77 2-3},
  pages={
          137-41
        }
}
The study concerned the opioid-receptor subtype on which dynorphin-(1-13) acts in in vitro isolated preparations. The potency of dynorphin-(1-13) relative to that of ethylketocyclazocine (Mr 2266), a representative kappa-receptor agonist, in inhibiting the electrically evoked contractions of the guinea-pig ileum was found to be similar to that found with either mouse was deferens or rabbit ileum. Moreover, Mr 2266 was found to be several-fold more effective than naloxone to antagonize the… Expand
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