Evidence that different cation chloride cotransporters in retinal neurons allow opposite responses to GABA.

@article{Vardi2000EvidenceTD,
  title={Evidence that different cation chloride cotransporters in retinal neurons allow opposite responses to GABA.},
  author={Noga Vardi and L L Zhang and John A. Payne and Peter Sterling},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 20},
  pages={7657-63}
}
GABA gating an anion channel primarily permeable to chloride can hyperpolarize or depolarize, depending on whether the chloride equilibrium potential (E(Cl)) is negative or positive, respectively, to the resting membrane potential (E(rest)). If the transmembrane Cl(-) gradient is set by active transport, those neurons or neuronal regions that exhibit opposite responses to GABA should express different chloride transporters. To test this, we immunostained retina for the K-Cl cotransporter (KCC2… CONTINUE READING
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