Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors

  title={Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors},
  author={Joanna C. Neill and Steven J. Cooper},
The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by the 5-HT2 receptor antagonist ritanserin; and by (±)cyanopindolol, a mixed 5-HT1A/5-HT1B receptor antagonist. In contrast, d-fenfluramine's effect was not antagonised by the 5-HT2… CONTINUE READING


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In vivo pharmacology of ICI 169 369 - a new 5 - HT 2 antagonist

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