Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells.

@article{Lowdell2002EvidenceTC,
  title={Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells.},
  author={Mark W. Lowdell and Rose Craston and David Samuel and Marion E Wood and Elena O'Neill and Vaskar Saha and Hugh Grant Prentice},
  journal={British journal of haematology},
  year={2002},
  volume={117 4},
  pages={821-7}
}
Although it has been known for more than 40 years that allogeneic immune responses cure leukaemias after bone marrow transplantation, autologous leukaemia-specific immunity remains controversial and its impact upon survival has not been established. Here we have tested 25 patients with de novo acute leukaemias, while in remission at completion of their anti-leukaemia therapy, for evidence of autologous cytolytic immunity to their leukaemic cells taken and cryopreserved at disease presentation… CONTINUE READING

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