Evidence that contact with connective tissue matrix is required for normal interaction between Schwann cells and nerve fibers

@article{Bunge1978EvidenceTC,
  title={Evidence that contact with connective tissue matrix is required for normal interaction between Schwann cells and nerve fibers},
  author={Richard P. Bunge and Mary Bartlett Bunge},
  journal={The Journal of Cell Biology},
  year={1978},
  volume={78},
  pages={943 - 950}
}
Explants of fetal rat sensory ganglia, cultured under conditions allowing axon and Schwann cell outgrowth in the absence of fibroblasts, occasionally develop nerve fascicles that are partially suspended in culture medium above the collagen substrate. In these suspended regions, fascicles are abnormal in that Schwann cells are decreased in number, are confined to occasional clusters along the fascicle, provide ensheathment for only a few axons at the fascicle periphery, and do not form myelin… CONTINUE READING

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