Evidence that cocaine slows cardiac conduction by an action on both AV nodal and His-Purkinje tissue in the dog.

@article{Tracy1991EvidenceTC,
  title={Evidence that cocaine slows cardiac conduction by an action on both AV nodal and His-Purkinje tissue in the dog.},
  author={C. Tracy and L. Bachenheimer and A. Solomon and M. M. Cohen and F. Kuhn and R. Jain and P. Corr and R. Gillis},
  journal={Journal of electrocardiology},
  year={1991},
  volume={24 3},
  pages={
          257-62
        }
}
The effects of intravenous cocaine (2 mg/kg) were tested on several indices of cardiac electrical activity in sedated dogs. These included sinus rate, PR, AH, and HV intervals; AV nodal effective refractory period (AVNERP); ventricular effective refractory period; QRS duration; and the QT interval. Cocaine induced significant changes in six control animals with an intact-functioning autonomic nervous systems. After pharmacologic autonomic blockade with propranolol plus propantheline, cocaine… Expand
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