Evidence that cocaine slows cardiac conduction by an action on both AV nodal and His-Purkinje tissue in the dog.

  title={Evidence that cocaine slows cardiac conduction by an action on both AV nodal and His-Purkinje tissue in the dog.},
  author={C. Tracy and L. Bachenheimer and A. Solomon and M. M. Cohen and F. Kuhn and R. Jain and P. Corr and R. Gillis},
  journal={Journal of electrocardiology},
  volume={24 3},
The effects of intravenous cocaine (2 mg/kg) were tested on several indices of cardiac electrical activity in sedated dogs. These included sinus rate, PR, AH, and HV intervals; AV nodal effective refractory period (AVNERP); ventricular effective refractory period; QRS duration; and the QT interval. Cocaine induced significant changes in six control animals with an intact-functioning autonomic nervous systems. After pharmacologic autonomic blockade with propranolol plus propantheline, cocaine… Expand
Cocaine and cardiovascular toxicity
Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine
Electrophysiologic in-vitro effects of cocaine and its metabolites.


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