Evidence that clozapine directly interacts on the GABAB receptor

  title={Evidence that clozapine directly interacts on the GABAB receptor},
  author={Ying Wu and Monica Blichowski and Zafiris J. Daskalakis and Z. Wu and Chun Che Liu and Miguel A. Cortez and O. Carter Snead},
Neurophysiological studies suggest that clozapine may facilitate &ggr;-aminobutyric acid (GABAergic) neurotransmission. Therefore, we studied the interaction between clozapine and the GABAB receptor (GABABR). We showed that clozapine, and not N-desmethylclozapine, which is a metabolite of clozapine, increased the binding of the GABABR antagonist, [3H]-CGP54626A, at GABABRs. Linear regression analysis showed that the correlation between the dose of clozapine and the increase of [3H]-CGP54626A… 

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