Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats.

@article{Keshavarzian2009EvidenceTC,
  title={Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats.},
  author={Ali Keshavarzian and Ashkan Farhadi and Christopher B Forsyth and Jayanthi Rangan and Shriram M. Jakate and Maliha W Shaikh and Ali Banan and Jeremy Z. Fields},
  journal={Journal of hepatology},
  year={2009},
  volume={50 3},
  pages={538-47}
}
BACKGROUND/AIMS Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary co-factor for ASH. But, it is not known whether endotoxemia is the consequence or the trigger for ALD. Accordingly, the aim of the current study was to determine whether endotoxemia… CONTINUE READING