Evidence that calcium may control neurite outgrowth by regulating the stability of actin filaments

  title={Evidence that calcium may control neurite outgrowth by regulating the stability of actin filaments},
  author={K L Lankford and Paul C. Letourneau},
  journal={The Journal of Cell Biology},
  pages={1229 - 1243}
We investigated the effects of calcium removal and calcium ionophores on the behavior and ultrastructure of cultured chick dorsal root ganglia (DRG) neurons to identify possible mechanisms by which calcium might regulate neurite outgrowth. Both calcium removal and the addition of calcium ionophores A23187 or ionomycin blocked outgrowth in previously elongating neurites, although in the case of calcium ionophores, changes in growth cone shape and retraction of neurites were also observed… CONTINUE READING
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