Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

Abstract

In epidermis the onset of terminal differentiation normally coincides with inhibition of integrin function and expression, thereby ensuring that differentiating cells are selectively expelled from the basal layer. However, when stratification of cultured human epidermal keratinocytes is prevented by reducing the calcium concentration of the medium to 0.1 mM… (More)

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