Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization.

@article{Danaher2008EvidenceTA,
  title={Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization.},
  author={Rachel N Danaher and Kerry M. Loomes and Bridget Louise Leonard and Lynda Whiting and Debbie L Hay and Lance Yi Xu and Edward W. Kraegen and Anthony R. J. Phillips and Garth J S Cooper},
  journal={Endocrinology},
  year={2008},
  volume={149 1},
  pages={154-60}
}
Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is strongly implicated in the pathogenesis of insulin resistance, but the physiological regulation of organ lipid is imperfectly understood. Here we report our systematic… CONTINUE READING

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