Evidence that acetylcholine released by gastrin and related polypeptides contributes to their effect on gastrointestinal motility.

@article{Vizi1973EvidenceTA,
  title={Evidence that acetylcholine released by gastrin and related polypeptides contributes to their effect on gastrointestinal motility.},
  author={Sylvester E. Vizi and Giulio Bertaccini and Mariannina Impicciatore and Joseph Knoll},
  journal={Gastroenterology},
  year={1973},
  volume={64 2},
  pages={
          268-77
        }
}
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199 Citations
Highly Influential Citations
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Background Citations
16
Methods Citations
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Results Citations
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199 Citations

Mechanism of inhibitory action of peptide YY on cholecystokinin-induced contractions of isolated dog ileum

Acetylcholine release from guinea‐pig ileum by parasympathetic ganglion stimulants and gastrin‐like polypeptides

  • E. Vizi
  • Biology, Chemistry
    British journal of pharmacology
  • 1973
The data suggest the presence in the parasympathetic ganglion cells of separate gastrointestinal hormone‐sensitive receptors in the guinea‐pig longitudinal muscle strip, which is mediated via α‐adrenoceptors since phentolamine prevented its action.

Evidence that the action of cholecystokinin octapeptide on the guinea pig ileum longitudinal muscle is mediated in part by substance P release from the myenteric plexus.

Structure-activity relationship of some analogues of gastrin and cholecystokinin on intestinal smooth muscle of the guinea-pig

It seems that the presence of tyrosine-O-sulphate is important for effective interaction between the peptides and the peptide-sensitive receptors of the ganglion cells of the Auerbach plexus.

Gastrointestinal hormone receptors on isolated smooth muscle cells from gastric antrum of the rabbit.

Gastrins and cholecystokinins release acetylcholine but not substance P from neurons in the guinea-pig taenia coli.

Both afferent and efferent nerves are implicated in cholecytokinin motor actions in the small intestine of the rat

The role of the intramural cholinergic innervation in the acid response of the parietal cell to gastrin derivatives.

Blockage of the terminal element of the cholinergic pathway can be involved in gastrin stimulation of the parietal cell in Pavlov pouches under insulin stimulation by pretreatment with LBC.

The responses of duodenal tension receptors in sheep to pentagastrin, cholecystokinin and some other drugs.

From the responses to bolus injections of humoral agents it is concluded that some alimentary hormones released after a meal may have a peripheral excitatory action on the tension receptor environment which causes increased afferent activity.

Receptor type for cholecystokinin on isolated intestinal muscle cells of the guinea pig

...

References

SHOWING 1-10 OF 29 REFERENCES

Acetylcholine-releasing effect of gastrin and related polypeptides.

Structures essential for the effect of cholecystokinin on the guinea pig small intestine in vitro.

It is concluded that the stimulating effect of cholecystokinin on the two muscle layers of the guinea pig small intestine is mediated via a cholinergic neural pathway withoutCholinergic synapses.

The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip

1 Noradrenaline and adrenaline reduce the output of acetylcholine by the guinea‐pig ileum longitudinal strip by up to 80%, both in resting conditions and after stimulation. The effect is graded with…

Action of caerulein on intestinal motility in man.

The actions of caerulein on the smooth muscle of the gastrointestinal tract and the gall bladder

The gall bladder, especially that of the guinea‐pig, appears to be very suitable for the bioassay of caerulein and related peptides, which are similar to those of cholecystokinin‐pancreozymin in the organs tested in situ or as isolated preparations.

Cholecystokinin-like activities in guinea pigs and in dogs of the C-terminal octapeptide (SQ 19,844) of cholecystokinin.

The synthetic C-terminal octapeptide of cholecystokinin (CCK), SQ 19,844, caused CCK-like contractile activities of excised gallbladder and ileal strips of guinea pigs, of gallbladder preparations in…

A comparison of the site of action of gastrin I on lower esophageal sphincter and antral circular smooth muscle.

The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuroeffector transmission; the inhibition of acetylcholine release

  • E. ViziJ. Knoll
  • Biology, Chemistry
    The Journal of pharmacy and pharmacology
  • 1971
The fact that noradrenaline released is capable of inhibiting acetylcholine release supports the concept that nordrenaline physiologically controls the release of acetylCholine.

The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α‐ and β‐adrenoceptors in the longitudinal muscle of the guinea‐pig ileum

It is assumed that α‐adrenoceptors in situ are stimulated mainly by circulating adrenaline and possibly noradrenaline and thus cause a prejunctional inhibition at the nerve‐smooth muscle junction.

Effect of cholecystokinin on small intestine.

The effect of highly purified cholecystokinin on gall-bladder and intestine was investigated in vivo and in vitro and it is possible that the hormone may play a role in the regulation of intestinal motility.