Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time.

@article{Mart2001EvidenceTA,
  title={Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time.},
  author={Octavi Mart{\'i} and Agustina Garc{\'i}a and Astrid Vall{\`e}s and Michael S. Harbuz and Antonio Armario},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 1},
  pages={129-36}
}
Because of its use as a negative reinforcer in animal studies and its potential pathological impact (e.g. post-traumatic stress disorder and depression), exposure to aversive stimuli is a relevant model for studying CNS plasticity. We present evidence that a single exposure to two predominantly emotional stressors [restraint in tubes and immobilization on wooden boards (IMO)] can modify the response of the hypothalamo-pituitary-adrenal (HPA) axis to a subsequent exposure to the same stressor… CONTINUE READING