Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology.

We examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following… CONTINUE READING