Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles.

@article{Tsukamoto2007EvidenceTS,
  title={Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles.},
  author={Hiroko Tsukamoto and Masa-aki Kawano and Takamasa Inoue and Teruya Enomoto and Ryou-u Takahashi and Naoki Yokoyama and Noriaki Yamamoto and Takeshi Imai and Kohsuke Kataoka and Yuki Yamaguchi and Hiroshi Handa},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2007},
  volume={12 11},
  pages={1267-79}
}
The simian virus 40 (SV40) particle is mainly composed of the major capsid protein termed VP1. VP1 self-assembles into virus-like particles (VLPs) of approximately 40 nm in diameter when over-expressed in bacteria or in insect cells, but purified VP1 does not form such a structure under physiological conditions, and thus, the mechanism of VP1 assembly is not well understood. Using a highly purified VP1 assembly/disassembly system in vitro, here we provide evidence that DNA is a factor that… CONTINUE READING

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