Evidence that SP1 modulates transcriptional activity of the multidrug resistance-associated protein gene.

@article{Zhu1996EvidenceTS,
  title={Evidence that SP1 modulates transcriptional activity of the multidrug resistance-associated protein gene.},
  author={Qichao Zhu and Melvin S. Center},
  journal={DNA and cell biology},
  year={1996},
  volume={15 2},
  pages={105-11}
}
In previous studies, we have cloned and sequenced a 5'-end region of the multidrug resistance-associated protein (MRP) gene that contains promoter activity as assessed through transient transfections of constructs contained in a pCAT basic reporter plasmid. In the present study, using a series of deletion mutants, evidence was obtained that the SP1 binding sites contained in the promoter are essential for optimal MRP transcriptional activity. These results were supported by the finding that… CONTINUE READING
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