Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing.

@article{Burns1999EvidenceTM,
  title={Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing.},
  author={Charles Geoffrey Burns and Ryoma Ohi and Adrian R. Krainer and Kathleen L. Gould},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 24},
  pages={13789-94}
}
The conserved CDC5 family of Myb-related proteins performs an essential function in cell cycle control at G(2)/M. Although c-Myb and many Myb-related proteins act as transcription factors, herein, we implicate CDC5 proteins in pre-mRNA splicing. Mammalian CDC5 colocalizes with pre-mRNA splicing factors in the nuclei of mammalian cells, associates with core components of the splicing machinery in nuclear extracts, and interacts with the spliceosome throughout the splicing reaction in vitro… CONTINUE READING