Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

@article{Eng1988EvidenceTD,
  title={Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.},
  author={Wai K Eng and Larry J Faucette and Randall K. Johnson and Rolf Sternglanz},
  journal={Molecular pharmacology},
  year={1988},
  volume={34 6},
  pages={
          755-60
        }
}
The budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe are both sensitive to camptothecin, an inhibitor of DNA topoisomerase I. An S. cerevisiae DNA repair mutant, rad52, is hypersensitive to the drug. In both species, topoisomerase I mutants totally lacking the enzyme are completely resistant to the drug. A strain with a mutation leading to a temperature-sensitive topoisomerase I exhibits temperature dependence in its in vivo response to camptothecin. A… CONTINUE READING
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