Evidence that DNA damage is associated to phenylalanine blood levels in leukocytes from phenylketonuric patients.

@article{Sitta2009EvidenceTD,
  title={Evidence that DNA damage is associated to phenylalanine blood levels in leukocytes from phenylketonuric patients.},
  author={Angela Maria Sitta and Vanusa Manfredini and Lidiana Biasi and Roberta Trem{\'e}a and Ida Vanessa D Schwartz and Moacir Wajner and Carmen Regla Vargas},
  journal={Mutation research},
  year={2009},
  volume={679 1-2},
  pages={13-6}
}
Phenylketonuria (PKU) is an inborn error of phenylalanine (Phe) metabolism, biochemically characterized by the accumulation of Phe and its metabolites in blood and tissues of affected patients. Treatment for PKU consists of a protein restricted diet supplemented with a mixture containing essential amino acids (other than Phe) and micronutrients. In recent years several authors have studied the pathomechanisms of the disease and demonstrated the existence of lipid and protein oxidative damage in… CONTINUE READING