Evidence that Argos is an antagonistic ligand of the EGF receptor

  title={Evidence that Argos is an antagonistic ligand of the EGF receptor},
  author={Javier Vin{\'o}s and Matthew Freeman},
Argos, the inhibitor of the Drosophila epidermal growth factor (EGF) receptor, remains the only known extracellular inhibitor of this family of receptors in any organism. The functional domain of Argos includes an atypical EGF domain and it is not clear whether it binds to the EGF receptor or if it acts via a distinct receptor to reduce Egfr activity indirectly. Here we present two lines of evidence that strongly suggest that Argos directly interacts with the EGF receptor. First, Argos is… CONTINUE READING

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