Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single Sites

@inproceedings{Karasov2010EvidenceTA,
  title={Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single Sites},
  author={Talia L Karasov and Philipp W. Messer and Dmitri A. Petrov},
  booktitle={PLoS genetics},
  year={2010}
}
Adaptation in eukaryotes is generally assumed to be mutation-limited because of small effective population sizes. This view is difficult to reconcile, however, with the observation that adaptation to anthropogenic changes, such as the introduction of pesticides, can occur very rapidly. Here we investigate adaptation at a key insecticide resistance locus (Ace) in Drosophila melanogaster and show that multiple simple and complex resistance alleles evolved quickly and repeatedly within individual… CONTINUE READING
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