Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety

@article{Kennett2005EvidenceT5,
  title={Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety},
  author={Guy A. Kennett and K. M. Pittaway and Thomas P Blackburn},
  journal={Psychopharmacology},
  year={2005},
  volume={114},
  pages={90-96}
}
Four non-selective 5-HT2C/5-HT2A receptor antagonists, mianserin (2–8 mg/kg), 1-naphthyl piperazine (1-NP) (0.5–1 mg/kg), ICI 169,369 (20 mg/kg) and LY 53857 (5 mg/kg), increased punished responding for a food reward in the rat Geller-Seifter test 30 min after subcutaneous (SC) administration. This property was shared by the benzodiazepine anxiolytic chlordiazepoxide (5 mg/kg SC). However, the selective 5-HT2A receptor antagonists ketanserin (0.2–1 mg/kg SC) and altanserin (0.5, 1 mg/kg SC) had… Expand
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TLDR
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