Evidence that 5′‐Cytidinediphosphocholine Can Affect Brain Phospholipid Composition by Increasing Choline and Cytidine Plasma Levels

@article{LpezCoviella1995EvidenceT5,
  title={Evidence that 5′‐Cytidinediphosphocholine Can Affect Brain Phospholipid Composition by Increasing Choline and Cytidine Plasma Levels},
  author={Ignacio L{\'o}pez-Coviella and J. Agut and Vahide Savci and Jose A. Ortiz and Richard J. Wurtman},
  journal={Journal of Neurochemistry},
  year={1995},
  volume={65}
}
Abstract: We examined the effects of orally administered 5′‐cytidinediphosphocholine (CDP‐choline) on arterial plasma choline and cytidine levels and on brain phospholipid composition in rats. Animals receiving a single oral dose of 100, 250, or 500 mg/kg showed peak plasma choline levels 6–8 h after drug administration (from 12 ± 1 to 17 ± 2, 19 ± 2, and 24 ± 2 µM, respectively). The area under the plasma choline curve at >14 µM, i.e., at a concentration that induces a net influx of choline… Expand
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TLDR
It is demonstrated that repeated oral CDP‐choline administration can increase the amounts of phospholipids in brain membranes, thus providing a rationale for using this compound in brain diseases that damage neurons. Expand
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Observations show that CDP-choline is converted to at least two major circulating metabolites, choline and cytidine, since both of these compounds are used in the biosynthesis of phosphatidylcholine, both may be involved in the long-term effects of the CDP -choline. Expand
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TLDR
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Blood‐brain barrier (BBB) transport of choline and certain choline analogs was studied in adult and suckling rats, and additionally compared in the paleocortex and neocortex of adult rats. SaturableExpand
Uptake of Exogenous PhosphatidyJserine by Human Neuroblastoma Cells Stimulates the Incorporation of [methyl‐l4C]Cholne into Phosphatidylcholine
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