Evidence that 5′‐Cytidinediphosphocholine Can Affect Brain Phospholipid Composition by Increasing Choline and Cytidine Plasma Levels

@article{LpezCoviella1995EvidenceT5,
  title={Evidence that 5′‐Cytidinediphosphocholine Can Affect Brain Phospholipid Composition by Increasing Choline and Cytidine Plasma Levels},
  author={Ignacio L{\'o}pez-Coviella and J. Agut and Vahide Savci and Jose A. Ortiz and Richard J. Wurtman},
  journal={Journal of Neurochemistry},
  year={1995},
  volume={65}
}
Abstract: We examined the effects of orally administered 5′‐cytidinediphosphocholine (CDP‐choline) on arterial plasma choline and cytidine levels and on brain phospholipid composition in rats. Animals receiving a single oral dose of 100, 250, or 500 mg/kg showed peak plasma choline levels 6–8 h after drug administration (from 12 ± 1 to 17 ± 2, 19 ± 2, and 24 ± 2 µM, respectively). The area under the plasma choline curve at >14 µM, i.e., at a concentration that induces a net influx of choline… 

Effects of cytidine 5'-diphosphocholine on plasma homocysteine levels in rat.

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Cytidine (5′) Diphosphocholine Modulates Dopamine K+‐evoked Release in Striatum Measured by Microdialysis

TLDR
Results show that long‐term treatment with CDP‐choline increases the K+ induced release of DA and suggest, in accordance with previous research, that by providing exogenous choline and cytidine, CDP-choline modulates dopaminergic transmission.

Cytidine 5′-Diphosphocholine Differentially Affects Hemostatic Parameters in Diverse Conditions in Rats: an Investigation via Thromboelastography

TLDR
Data implicate that acute but not chronic CDP-choline administration may differentially alter the hemostatic parameters under diverse conditions, and the drug may produce a hypercoagulable state in activated situations but cause opposite effects under normal in vitro conditions.

CYTIDINE 5′‐DIPHOSPHOCHOLINE RESTORES BLOOD FLOW OF SUPERIOR MESENTERIC AND RENAL ARTERIES AND PROLONGS SURVIVAL TIME IN HAEMORRHAGED ANAESTHETIZED RATS

TLDR
Results indicate that both centrally and peripherally injected CDP‐choline can restore SMA and RA flow, together with a partial reversal of hypotension and an increase in the survival time of rats.

Centrally injected CDP‐choline increases plasma vasopressin levels by central cholinergic activation

TLDR
In conclusion, intracerebroventricularly injected CDP‐choline can increase plasma vasopressin levels by activating central nicotinic cholinergic receptors through the activation of presynaptic Cholinergic mechanisms.
...

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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