Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle.

  title={Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle.},
  author={Luc Pellerin and G Pellegri and P G Bittar and Yves Charnay and Constantin Bouras and Jody L Martin and Nephi Stella and Pierre J. Magistretti},
  journal={Developmental neuroscience},
  volume={20 4-5},
Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to maintain synaptic transmission, particularly during periods of intense activity. Since lactate does not cross the blood-brain barrier easily, blood-borne lactate cannot be a significant source. In vitro studies by several laboratories indicate that astrocytes release large amounts of lactate. In 1994, we proposed a mechanism whereby lactate… CONTINUE READING
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Lactate dehydrogenase isoenzymes in the central nervous system

  • W Gerhardt-Hansen
  • Dan Med Bull
  • 1968
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