Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.

@article{Cooper1979EvidenceSA,
  title={Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.},
  author={Keith E. Cooper and N. W. Kasting and Karl P. Lederis and Warren L. Veale},
  journal={The Journal of physiology},
  year={1979},
  volume={295},
  pages={33-45}
}
1. The antipyretic effect of arginine vasopressin (AVP) introduced into the brain by push-pull perfusion was investigated in the sheep. 2. Control perfusions with sucrose solutions had no effect on fevers induced by a bacterial endotoxin. Sucrose solutions containing AVP (4.0 microgram/ml.) perfused at 40 microliter./min had significant antipyretic activity, reducing the two peaks of the fever but had no effect on resting body temperature. 3. Loci in which AVP induced antipyresis were limited… CONTINUE READING