Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.

@article{Gonalves2012EvidenceSA,
  title={Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.},
  author={Isabel Gonçalves and Andreas Edsfeldt and Na Young Ko and Helena Grufman and Katarina A. Berg and Harry Bj{\"o}rkbacka and Mihaela Nitulescu and Ana Flor Persson and Marie Nilsson and Cornelia Prehn and Jerzy Adamski and Jan Nilsson},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 6},
  pages={1505-12}
}
OBJECTIVE To determine whether the level of lysophosphatidylcholine (lysoPC) generated by lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with severity of inflammation in human atherosclerotic plaques. Elevated plasma Lp-PLA2 is associated with increased cardiovascular risk. Lp-PLA2 inhibition reduces atherosclerosis. Lp-PLA2 hydrolyzes low-density lipoprotein-oxidized phospholipids generating lysoPCs. According to in vitro studies, lysoPCs are proinflammatory but the… CONTINUE READING