Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study

@article{Turner2004EvidenceOW,
  title={Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study},
  author={Martin R. Turner and Annachiara Cagnin and Federico E. Turkheimer and Ccj Miller and Christopher E. Shaw and David J. Brooks and P. Nigel Leigh and Richard B. Banati},
  journal={Neurobiology of Disease},
  year={2004},
  volume={15},
  pages={601-609}
}

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

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A comprehensive review of PET studies investigating ALS and ALS-mimicking conditions, articles selecting specific subsets of patients (with bulbar or spinal onset), studies investigating patients with familial type of ALS, studies evaluating the role of the white matter in ALS and papers evaluating the diagnostic sensitivity of PET in ALS patients are presented.

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It is proposed that PET imaging using [11C](R)PK11195 may be a valuable tool for detecting neuroinflammation in the brain of newborns born to mothers with chorioamnionitis.

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This study provides evidence for differences in the distribution of reduced cortical [11C]flumazenil binding in homD90A compared with sALS patients and hypothesize that this might reflect differences in cortical neuronal vulnerability.

In vivo evidence for microglial activation in neurodegenerative dementia

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This large FDG PET investigation provided unprecedented evidence of relatively increased metabolism in the amygdalae, midbrain and pons in ALS patients as compared with control subjects, possibly due to local activation of astrocytes and microglia.
...

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