Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas.

  title={Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas.},
  author={Yun Wang and J J DiGiovanna and J. Bender Stern and Thomas J. Hornyak and Mark A. Raffeld and S G Khan and Kyu-Seon Oh and Mary Christine Hollander and Philip A. Dennis and Kenneth H Kraemer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 15},
To look for a direct role of ultraviolet radiation (UV) exposure in cutaneous melanoma induction, we studied xeroderma pigmentosum (XP) patients who have defective DNA repair resulting in a 1000-fold increase in melanoma risk. These XP melanomas have the same anatomic distribution as melanomas in the general population. We analyzed laser capture microdissection samples of skin melanomas from XP patients studied at the National Institutes of Health. The tumor suppressor gene PTEN was sequenced… CONTINUE READING