Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome

@article{Wu1995EvidenceOT,
  title={Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome},
  author={J. C. Wu and Chii Ming Chen and I J Sheen and S. Daniel Lee and H M Tzeng and Kong Bung Choo},
  journal={Hepatology},
  year={1995},
  volume={22}
}
To study sexual transmission of hepatitis D virus (HDV), 52 spouses of 56 index patients were observed and HDV genomes from antibody to HDV (anti‐HDV)‐positive couples were sequenced. Of the spouses, 11 (21%) were serum HBsAg positive, 3 (27%) of whom were also anti‐HDV positive. The HDV sequences between spouses were found to be nearly identical (98% to 98.8%) in the region analyzed (nt 911 to nt 1260). Only one couple showed an identity >90% with the genotype I HDV strains. The HDV sequences… Expand
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