Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome

@article{Wu1995EvidenceOT,
  title={Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome},
  author={J. C. Wu and Chii Ming Chen and I J Sheen and S. Daniel Lee and H M Tzeng and Kong Bung Choo},
  journal={Hepatology},
  year={1995},
  volume={22}
}
To study sexual transmission of hepatitis D virus (HDV), 52 spouses of 56 index patients were observed and HDV genomes from antibody to HDV (anti‐HDV)‐positive couples were sequenced. Of the spouses, 11 (21%) were serum HBsAg positive, 3 (27%) of whom were also anti‐HDV positive. The HDV sequences between spouses were found to be nearly identical (98% to 98.8%) in the region analyzed (nt 911 to nt 1260). Only one couple showed an identity >90% with the genotype I HDV strains. The HDV sequences… Expand
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62 Citations

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Citation Type

Evidence of transmission of hepatitis B virus to spouses from sequence analysis of the viral genome
  • T. Huo, J. Wu, +4 authors S. Lee
  • Biology, Medicine
  • Journal of gastroenterology and hepatology
  • 1998
TLDR
It is demonstrated that sequence analyses can correlate well with epidemiological findings and confirm the value of the molecular approach for linked infections of HBV through heterosexual contact between spouses. Expand
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In most family units, HDV-infected members harbored nearly identical strains of HDV, and provide molecular support that HDV infection can be transmitted within the family, highlighting the role of inapparent transmission through personal contacts. Expand
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TLDR
The prevalence of intergenotypic recombination between HDV genotypes 1 and 2 in a Vietnamese HBsAg‐positive patient is demonstrated and a newly identified recombinant of HDVgenotype 1 and HDV 2 is reported. Expand
The predominance of hepatitis delta virus genotype I among chronically infected Italian patients
TLDR
It is concluded that in Italy, where HDV infection has been endemic, the overwhelmingly predominant genotype of HDV is genotype I, and this genotype appeared to be associated with a broad spectrum of chronic disease. Expand
Molecular analysis of hepatitis D virus infection in Miyako Island, a small Japanese island
TLDR
A geographical factor was revealed to be significant with regard to HDV infection, which was spread in a closed environment and the HDV genomes on Miyako Island were similar to the Japanese and Taiwan isolates of HDV genotype II. Expand
Dynamics of hepatitis D (delta) virus genotype 3 in the Amazon region of South America.
TLDR
It is suggested that the measures implemented to control HBV transmission resulted in the control of HDV/3 spreading in South America, especially after the important raise in this infection associated with a huge mortality during the 1950s up to the 1970s. Expand
Molecular Phylogenetic Analysis of Iranian HDV Complete Genome
TLDR
Genetic variability and heterogeneity of the HDV species isolated from different geographical areas were confirmed and predicted HDAg sequence of IR-1 revealed the most homology with those of Italian and Lebanese isolates. Expand
Transmission of hepatitis D virus between spouses: A longitudinal study of the first reported Canadian case
TLDR
The ongoing risk of HDV superinfection due to long-term co-habitation or sexual transmission in CHB patients is highlighted, with post-transmission longitudinal sequence revealing specific nucleotide substitutions between both spouse’s HDV genome sequences. Expand
Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela.
TLDR
It was concluded that the serious delta hepatitis outbreaks characterized epidemiologically in the Yucpa Amerindians were caused by HDV genotype III isolates that were related to HDV Genotype III isolate from other regions of South America. Expand
The impact of traveling to endemic areas on the spread of hepatitis E virus infection: Epidemiological and molecular analyses
TLDR
E Epidemiological and molecular analyses strongly indicate that most cases of HEV infection originated from travel to HEV‐endemic areas, andHEV infection does occur in this area. Expand
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