Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome

  title={Evidence of transmission of hepatitis D virus to spouses from sequence analysis of the viral genome},
  author={J. C. Wu and C. M. Chen and I J Sheen and S. D. Lee and H M Tzeng and Kong Bung Choo},
To study sexual transmission of hepatitis D virus (HDV), 52 spouses of 56 index patients were observed and HDV genomes from antibody to HDV (anti‐HDV)‐positive couples were sequenced. Of the spouses, 11 (21%) were serum HBsAg positive, 3 (27%) of whom were also anti‐HDV positive. The HDV sequences between spouses were found to be nearly identical (98% to 98.8%) in the region analyzed (nt 911 to nt 1260). Only one couple showed an identity >90% with the genotype I HDV strains. The HDV sequences… 

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