Evidence of the role of angiotensin AT(1) receptors in remote renal preconditioning of myocardium.

@article{Singh2004EvidenceOT,
  title={Evidence of the role of angiotensin AT(1) receptors in remote renal preconditioning of myocardium.},
  author={Devinder Pal Singh and Kanwaljit Chopra},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2004},
  volume={26 2},
  pages={117-22}
}
The underlying mechanisms of myocardial preconditioning after a brief period of renal ischemia-reperfusion are unknown. The phenomenon itself and the involvement of AT(1) angiotensin receptors was therefore investigated using an in vivo rat model of acute myocardial infarction. Anesthetized rats underwent a left thoracotomy and pericardiotomy. A laparotomy was performed to expose the left renal artery. Animals were then preconditioned with four episodes, each consisting of 5 min of renal artery… CONTINUE READING

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