Evidence of the modulation of mRNA splicing fidelity in humans by oxidative stress and p53.

@article{Disher2007EvidenceOT,
  title={Evidence of the modulation of mRNA splicing fidelity in humans by oxidative stress and p53.},
  author={Kim Disher and Adonis Skandalis},
  journal={Genome},
  year={2007},
  volume={50 10},
  pages={946-53}
}
The majority of human genes generate mRNA splice variants and while there is little doubt that alternative splicing is an important biological phenomenon, it has also become apparent that some splice variants are associated with disease. To elucidate the molecular mechanisms responsible for generating aberrant splice variants, we have investigated alternative splicing of the human genes HPRT and POLB following oxidative stress in different genetic backgrounds. Our study revealed that splicing… CONTINUE READING

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