Evidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkey.

@article{Eichling1974EvidenceOT,
  title={Evidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkey.},
  author={John O. Eichling and Marcus E. Raichle and Robert L. Grubb and Michel M. Ter-Pogossian},
  journal={Circulation research},
  year={1974},
  volume={35 3},
  pages={
          358-64
        }
}
The extraction of 15 O-labeled water by the brain during a single capillary transit was studied in vivo in 20 adult rhesus monkeys by external detection of the time course of the tracer subsequent to the internal carotid injection of 0.2 ml of whole blood labeled with H 2 15 O. The data showed that labeled water does not freely equilibrate with the exchangeable water in the brain when the mean cerebral blood flow exceeds 30 ml/100 g min -1 . At the normal cerebral blood flow in the rhesus… CONTINUE READING

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