Evidence of the direct interaction between spontaneously occurring anti-factor VIII autoantibody and intravenous immunoglobulin.


A previously normal female (39-year-old) who developed anti-factor VIII autoantibodies experienced massive and prolonged bleeding after the emergency operation for intramuscular hemorrhage in her left calf. Administration of high-dose intravenous immunoglobulin, 400 mg/kg for 5 consecutive days, decreased the antibody titer from 115 Bethesda units/ml (B U… (More)


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