Evidence of the depletion of susceptibles effect in non-experimental pharmacoepidemiologic research.

@article{Moride1994EvidenceOT,
  title={Evidence of the depletion of susceptibles effect in non-experimental pharmacoepidemiologic research.},
  author={Yola Moride and Lucien A Abenhaim},
  journal={Journal of clinical epidemiology},
  year={1994},
  volume={47 7},
  pages={731-7}
}
Past experience with a drug may modify the risk of adverse event associated with current use of this drug. This effect was investigated empirically with a study on non-steroidal anti-inflammatory drugs (NSAIDs)-gastropathy. A hospital-based case-control study was conducted with 244 cases of upper gastrointestinal bleeding (UGIB) age 68 and over and 615 matched controls. Data on all medications dispensed to the study patients during the 3 years preceding admission were obtained from the Quebec… CONTINUE READING