Evidence of the Mechanism of Ouabain Inhibition of Cation Activated Adenosine Triphosphatase

@article{Charnock1963EvidenceOT,
  title={Evidence of the Mechanism of Ouabain Inhibition of Cation Activated Adenosine Triphosphatase},
  author={John S. Charnock and Robert L. Post},
  journal={Nature},
  year={1963},
  volume={199},
  pages={910-911}
}
OUABAIN has been shown to inhibit electrolyte transport in a number of tissues, including erythrocytes1,2, brain and kidney3,4. Ouabain also inhibits that adenosine triphosphatase obtained from membrane and sub-cellular preparations which is stimulated by sodium plus potassium ions5–7. Recent work has shown that this enzyme must play an important part in the mechanism of active ion transport7–10. 

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