Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology.

@article{Cranfield2016EvidenceOT,
  title={Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology.},
  author={Charles G Cranfield and Thomas Berry and Stephen A. Holt and Khondker Rufaka Hossain and Anton P. Le Brun and Sonia Carne and Heba Al Khamici and Hans Gerard L. Coster and Stella M Valenzuela and Bruce Walter Cornell},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2016}
}
This study explains the importance of the phosphate moiety and H3O+ in controlling the ionic flux through phospholipid membranes. We show that despite an increase in the H3O+ concentration when the pH is decreased, the level of ionic conduction through phospholipid bilayers is reduced. By modifying the lipid structure, we show the dominant determinant of membrane conduction is the hydrogen bonding between the phosphate oxygens on adjacent phospholipids. The modulation of conduction with pH is… CONTINUE READING
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