Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders

  title={Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders},
  author={Salvador Mar{\'i}-Bauset and Itziar Zazpe and Amelia Mar{\'i}-Sanchis and Agust{\'i}n Llopis-Gonz{\'a}lez and Maria Manuela Morales-Su{\'a}rez-Varela},
  journal={Journal of Child Neurology},
  pages={1718 - 1727}
In autism spectrum disorders, many parents resort to alternative treatments and these are generally perceived as risk free. Among these, the most commonly used is the gluten-free, casein-free diet. The objective of this work was to conduct a systematic review of studies published from 1970 to date related to the gluten-free, casein-free diet in autism spectrum disorder patients. Few studies can be regarded as providing sound scientific evidence since they were blinded randomized controlled… 

Gluten-free and casein-free diets in the therapy of autism

The findings of this study suggest additional effects of a gluten-free and casein-free diet on comorbid problems of autism such as gastrointestinal symptoms, concentration, and attention.

A review of gluten- and casein-free diets for treatment of autism: 2005-2015.

While strong empirical support for the GFCF diet in ASD is currently lacking, studies point to the need for identifying subsets of individuals (e.g., those with documented gastrointestinal abnormalities) who may be the best responders to the G FCF diet.

A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet

The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD, and the most relevant and updated studies about dietary interventions related to ASDs etiopathogenesis were gathered.

Gluten-free /Casein-free Diet Improves Behavior in a Subset of Children with an Autism Spectrum Disorder

All children with regressive ASDs on the GFCF diet reported improvement in behavior and/or language and in this cohort, the G FCF diet was generally well-tolerated and without any serious adverse effects.

Nutritional Impact of a Gluten-Free Casein-Free Diet in Children with Autism Spectrum Disorder

Children with autism spectrum disorder on a gluten-free casein-free (GFCF) diet had a lower weight, body mass index, and total energy, pantothenic acid, calcium, phosphorus and sodium intake, but a higher intake of fiber, legumes, and vegetables.

Influence of a Gluten-free, Casein-free Diet on Behavioral Disturbances in Children and Adolescents Diagnosed with Autism Spectrum Disorder: A 3-month Follow-up Pilot Study

A GFCF diet followed for three months do neither show significant changes in behavioral symptoms of autism nor in urine concentrations of beta-casomorphin using chromatographic detection, however, further studies are needed including elements of placebo and double-blindness and more sophisticated beta-Casomorphin detection techniques to better define subjects who might benefit from these diets.

GFCF Diet in ASD

Genetic and environmentally induced interpersonal differences were found in intestinal membrane permeability and blood brain barrier integrity as well as in activity of peptidase enzymes, which probably affect responsiveness to the diet.

Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial

This study suggested that GFD may be effective in controlling gastrointestinal symptoms and ASD behaviors in children with ASD.

Nutritional management of (some) autism: a case for gluten- and casein-free diets?

  • P. Whiteley
  • Medicine
    Proceedings of the Nutrition Society
  • 2014
Several pertinent aspects onwards to an effect of food in some cases of autism including research on the pharmacological activity of food metabolites, immune response, issues with gut barrier function and some contribution from the gut microbiota represent promising areas in need of far greater research inspection.



Effects of Gluten Free / Casein Free Diet in Young Children with Autism: A Pilot Study

The results do not support use of a GFCF diet in ASD, and it is possible that a greater period of time is required for treatment before gains can be observed.

[Gluten-free diet in infantile autism. A therapeutic trial].

  • E. Sponheim
  • Medicine, Psychology
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 1991
The gluten-free diet seemed to be another negative factor leading to further social isolation in this group of highly socially handicapped patients and families.

Gluten and casein free diets in autism: a study of the effects on food choice and nutrition.

  • E. Cornish
  • Medicine
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
  • 2002
Whether the removal of major dietary staples placed children with autism at risk of nutrient deficiency and compares their food choice with ASD children not following gluten and/or casein free diets is examined.

A Gluten-Free Diet as an Intervention for Autism and Associated Spectrum Disorders: Preliminary Findings

Results suggested that participants on a gluten-free diet showed an improvement on a number of behavioural measures, however there was no significant decrease in specific urinary compounds excreted when compared with controls and a gluten challenge group.

Gluten- and casein-free dietary intervention for autism spectrum conditions

Evidence suggestive that a gluten-free or casein-free diet can ameliorate core and peripheral symptoms and improve developmental outcome in some cases of autism spectrum conditions is examined.

The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders

The results suggest that dietary intervention may positively affect developmental outcome for some children diagnosed with ASD and is unable to disqualify potential effects derived from intervention outside of dietary changes.

Food allergy and infantile autism.

The results lead us to hypothesise a relationship between food allergy and infantile autism as has already been suggested for other disturbances of the central nervous system.