Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders

@article{MarBauset2014EvidenceOT,
  title={Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders},
  author={Salvador Mar{\'i}-Bauset and Itziar Zazpe and Amelia Mar{\'i}-Sanchis and Agust{\'i}n Llopis-Gonz{\'a}lez and Maria Manuela Morales-Su{\'a}rez-Varela},
  journal={Journal of Child Neurology},
  year={2014},
  volume={29},
  pages={1718 - 1727}
}
In autism spectrum disorders, many parents resort to alternative treatments and these are generally perceived as risk free. Among these, the most commonly used is the gluten-free, casein-free diet. The objective of this work was to conduct a systematic review of studies published from 1970 to date related to the gluten-free, casein-free diet in autism spectrum disorder patients. Few studies can be regarded as providing sound scientific evidence since they were blinded randomized controlled… 

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The findings of this study suggest additional effects of a gluten-free and casein-free diet on comorbid problems of autism such as gastrointestinal symptoms, concentration, and attention.

A review of gluten- and casein-free diets for treatment of autism: 2005-2015.

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The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD, and the most relevant and updated studies about dietary interventions related to ASDs etiopathogenesis were gathered.

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Nutritional Impact of a Gluten-Free Casein-Free Diet in Children with Autism Spectrum Disorder

Children with autism spectrum disorder on a gluten-free casein-free (GFCF) diet had a lower weight, body mass index, and total energy, pantothenic acid, calcium, phosphorus and sodium intake, but a higher intake of fiber, legumes, and vegetables.

Influence of a Gluten-free, Casein-free Diet on Behavioral Disturbances in Children and Adolescents Diagnosed with Autism Spectrum Disorder: A 3-month Follow-up Pilot Study

A GFCF diet followed for three months do neither show significant changes in behavioral symptoms of autism nor in urine concentrations of beta-casomorphin using chromatographic detection, however, further studies are needed including elements of placebo and double-blindness and more sophisticated beta-Casomorphin detection techniques to better define subjects who might benefit from these diets.

GFCF Diet in ASD

Genetic and environmentally induced interpersonal differences were found in intestinal membrane permeability and blood brain barrier integrity as well as in activity of peptidase enzymes, which probably affect responsiveness to the diet.

Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial

This study suggested that GFD may be effective in controlling gastrointestinal symptoms and ASD behaviors in children with ASD.

Nutritional management of (some) autism: a case for gluten- and casein-free diets?

  • P. Whiteley
  • Medicine
    Proceedings of the Nutrition Society
  • 2014
Several pertinent aspects onwards to an effect of food in some cases of autism including research on the pharmacological activity of food metabolites, immune response, issues with gut barrier function and some contribution from the gut microbiota represent promising areas in need of far greater research inspection.
...

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