Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA.

@article{EyreWalker1999EvidenceOS,
  title={Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA.},
  author={Adam Eyre-Walker},
  journal={Genetics},
  year={1999},
  volume={152 2},
  pages={675-83}
}
It has been suggested that mutation bias is the major determinant of base composition bias at synonymous, intron, and flanking DNA sites in mammals. Here I test this hypothesis using population genetic data from the major histocompatibility genes of several mammalian species. The results of two tests are inconsistent with the mutation hypothesis in coding, noncoding, CpG-island, and non-CpG-island DNA, but are consistent with selection or biased gene conversion. It is argued that biased gene… CONTINUE READING

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