Evidence of reciprocal tertiary interactions between conserved motifs involved in organizing RNA structure essential for internal initiation of translation.

@article{FernndezMiragall2006EvidenceOR,
  title={Evidence of reciprocal tertiary interactions between conserved motifs involved in organizing RNA structure essential for internal initiation of translation.},
  author={Olga Fern{\'a}ndez-Miragall and Ricardo Ramos and Jorge Ramajo and Encarnaci{\'o}n Mart{\'i}nez-Salas},
  journal={RNA},
  year={2006},
  volume={12 2},
  pages={223-34}
}
Internal ribosome entry site (IRES) elements consist of highly structured RNA regions that determine internal initiation of translation. We have previously shown that the foot-and-mouth disease virus (FMDV) IRES contains a GNRA tetraloop spanning residues G178UAA181. Here we show that tertiary RNA interactions dependent on the GNRA motif determine the structural organization of the central domain. By using mutational analysis in combination with RNA probing, we have identified distant… CONTINUE READING

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