Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2.

@article{Osseni2000EvidenceOP,
  title={Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2.},
  author={R A Osseni and Patrice Rat and Andr{\'e} Bogdan and J. M. Warnet and Yvan Touitou},
  journal={Life sciences},
  year={2000},
  volume={68 4},
  pages={387-99}
}
The aim of this study was to evaluate melatonin cytotoxicity by measuring its effects on various cellular targets. Cell viability, intracellular reduced glutathione (GSH) level, and reactive oxygen species (ROS) production were assessed in the human liver cell line (HepG2), after incubation with increasing melatonin concentrations (0.1-10,000 microM). The… CONTINUE READING