Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.

@article{Baarine2012EvidenceOO,
  title={Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.},
  author={Mauhamad Baarine and Pierre Andreoletti and Anne Athias and Thomas Nury and Amira Zarrouk and K{\'e}vin Ragot and Anne Vejux and J. M. Riedinger and Zilal Kattan and Ginette Bess{\`e}de and Doriane Trompier and St{\'e}phane Savary and Mustapha Cherkaoui-Malki and G{\'e}rard Lizard},
  journal={Neuroscience},
  year={2012},
  volume={213},
  pages={1-18}
}
X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of the peroxisomal ATP-binding cassette transporter D (ABCD1) and from single peroxisomal enzyme deficiency (Acyl-CoA oxidase1: ACOX1), respectively. As these proteins are involved in the catabolism of very long chain fatty acids (VLCFA: C24:0, C26:0), X-ALD and P-NALD patients are characterized by the accumulation of VLCFA in… CONTINUE READING