Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis.

@article{Higgins2019EvidenceOO,
  title={Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis.},
  author={Cassie Higgins and B Holly Smith and Keith Matthews},
  journal={British journal of anaesthesia},
  year={2019},
  volume={122 6},
  pages={
          e114-e126
        }
}
Opioid-induced Hyperalgesia in Patients With Chronic Pain
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Opioid taper was associated with improvements in experimental pain responses without a decline in function and quality of life, suggestive of diminished opioid-induced hyperalgesia in this clinical sample.
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TLDR
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Evidence is provided that aerobic exercise reduces pain sensitisation in individuals with musculoskeletal pain, and further work is needed to determine whether this translates to improved patient outcomes, including reduced disability and greater quality of life.
Opioid dependence disorder and comorbid chronic pain: comparison of groups based on patient-attributed direction of the causal relationship between the two conditions
TLDR
Two distinct clinical populations were identified, determined by how participants perceive the causal relationship between opioid dependence disorder and chronic pain: those reporting that pain caused opioid dependence Disorder were characterised by poorer pain-related health and more illicit use of drugs with analgesic properties and poorer general health.
How do people who use drugs receiving Opioid Medication Therapy perceive their treatment ? A multicentre study
TLDR
Involving patient points of view in therapeutic strategies decisions could help enhance positive views among PWUD on OMT and help PWUD towards their recovery.
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References

SHOWING 1-10 OF 62 REFERENCES
Do opioids induce hyperalgesia in humans? An evidence-based structured review.
TLDR
There is not sufficient evidence to support or refute the existence of OIH in humans except in the case of normal volunteers receiving opioid infusions, as measured by secondary hyperalgesia.
A negative correlation between hyperalgesia and analgesia in patients with chronic radicular pain: is hydromorphone therapy a double-edged sword?
TLDR
A 4-week regimen of open-label hydromorphone therapy results in a dose-dependent OIH, which negatively correlates with its analgesic effect, and future randomized, controlled, and blinded studies are needed to verify these preliminary results.
Opioid-induced hyperalgesia: a clinical challenge.
TLDR
Findings are presented that add further weight to the importance of the NMDA receptor in acute OIH, which has the benefits of more closely mimicking the clinical situation than some previous models, and as such their findings may be more directly translatable.
Comparison of pain models to detect opioid-induced hyperalgesia
TLDR
Cold pain is the most suitable of the methods tested to detect opioid-induced hyperalgesia and is consistent with its sensitivity to detect opioids analgesia.
Is opioid-induced hyperalgesia reversible? A study on active and former opioid addicts and drug naïve controls.
TLDR
It is suggested that altered pain perception in OAs is a reversible phenomenon that may require a long period of abstinence to reset, rather than being an individual long-term stable trait.
Opioid-Induced Hyperalgesia
TLDR
Four proposed mechanisms are being considered in the present review to explain OIH including; N-methyl-D-aspartate (NMDA) receptor activation; spinal dynorphin; descending facilitation; and finally decreased reuptake and enhanced nociceptive response.
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