Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci

  title={Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci},
  author={Dale J. Hedges and Kara L. Hamilton-Nelson and Stephanie J Sacharow and Laura D. Nations and Gary W. Beecham and Zhanna M Kozhekbaeva and Brittany L Butler and Holly N. Cukier and Patrice L. Whitehead and Deqiong Ma and James M. Jaworski and Lubov Nathanson and Joycelyn M. Lee and Stephen L. Hauser and Jorge Oksenberg and Michael L. Cuccaro and Jonathan L. Haines and John R. Gilbert and Margaret A. Pericak-Vance},
  booktitle={Molecular autism},
BACKGROUND Autism spectrum disorders (ASD) represent a group of neurodevelopmental disorders characterized by a core set of social-communicative and behavioral impairments. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain, acting primarily via the GABA receptors (GABR). Multiple lines of evidence, including altered GABA and GABA receptor expression in autistic patients, indicate that the GABAergic system may be involved in the etiology of autism. METHODS As… CONTINUE READING
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