Evidence of melatonin synthesis in the cumulus oocyte complexes and its role in enhancing oocyte maturation in vitro in cattle

@article{ElRaey2011EvidenceOM,
  title={Evidence of melatonin synthesis in the cumulus oocyte complexes and its role in enhancing oocyte maturation in vitro in cattle},
  author={Mohamed A El-Raey and Masaya Geshi and Tam{\'a}s Somfai and Masahiro Kaneda and Makoto Hirako and Alaa E. Abdel-Ghaffar and Gamal Abd El-Raheim Sosa and Mahmoud E.A. Abou El-Roos and Takashi Nagai},
  journal={Molecular Reproduction and Development},
  year={2011},
  volume={78}
}
Melatonin is a multifunctional molecule that mediates several circadian and seasonal reproductive processes. The exact role of melatonin in modulating reproduction, however, is not fully understood—especially its effects on the ovarian follicles and oocytes. This study was conducted to investigate the expressions of the ASMT and melatonin‐receptor MTNR1A and MTNR1B genes in bovine oocytes and their cumulus cells, as well as the effects of melatonin on oocyte nuclear and cytoplasmic maturation… 
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Beneficial Effects of Melatonin on the In Vitro Maturation of Sheep Oocytes and Its Relation to Melatonin Receptors
TLDR
The beneficial effects of melatonin indicated that its roles in regulating sheep oocyte maturation may be mediated mainly by the MT1 receptor.
Beneficial effects of melatonin on bovine oocytes maturation: a mechanistic approach
TLDR
Mechanistic explorations revealed that melatonin supplementation during bovine oocytes maturation significantly up‐regulated the expressions of oocyte maturation‐associated genes and that LHR1/2, EGFR are involved in signal transduction and epigenetic reprogramming.
Effects of melatonin on oocyte developmental competence and the role of melatonin receptor 1 in juvenile goats
TLDR
It is showed that melatonin improves oocyte developmental competence in juvenile goats by reducing ROS levels and improving mitochondrial activity and the role of the membrane receptors.
Profile of melatonin and its receptors and synthesizing enzymes in cumulus–oocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated mechanism
TLDR
It is suggested that sheep COCs can synthesize melatonin, but this ability is decreased with increasing follicle diameter, and E2 play an important role in regulated the expression of MT1 and MT2 as well as melatonin synthesis in sheep C OCs through the ER pathway.
Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor
TLDR
The results indicate that the MT2 receptor mediated the stimulatory effects of melatonin on porcine cumulus expansion and subsequent embryo development.
The effects of melatonin on bovine uniparental embryos development in vitro and the hormone secretion of COCs
TLDR
It could be concluded that melatonin had beneficial effects on bovine oocyte in vitro maturation, COC hormone secretion, early development of subsequent parthenogenetic and androgenetic embryos and the regulatory mechanism of melatonin on steroids synthesis was revealed.
Effects of melatonin on the synthesis of estradiol and gene expression in pig granulosa cells
TLDR
It is found melatonin could stimulate the synthesis of estradiol in pig GCs and the functions of two DEGs, NOTCH2 and FILIP1L, were studied, which deepens the understanding of melatonin's effects onGCs and oocyte.
Protective effects of melatonin on the in vitro developmental competence of bovine oocytes.
TLDR
Results showed that the nuclear and cytoplasmic maturation, characterized by first polar body extrusion, normal distribution of cortical granules and mitochondria, as well as increased mitochondrial membrane potential, were significantly improved in 10-9  mol/L melatonin-treated oocytes.
Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events
TLDR
Melatonin significantly improved the cytoplasmic maturation of bovine oocytes by improving the normal distribution of organelles, increasing intracellular GSH and ATP levels, enhancing antioxidant gene expression levels, and modulating fertilization‐related events, all of which resulted in increased fertilization capacity and developmental ability.
Melatonin‐induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence
TLDR
It is demonstrated that supplementing melatonin to in vitro maturation (IVM) medium enhances IVM rate, lipid droplets (LDs) accumulation as well as triglyceride content in porcine oocytes, which suggests that melatonin regulates the transcription of mtDNA through up‐regulation of DNMT1 and mtDNA methylation.
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