Evidence of melanogenesis in porcine retinal pigment epithelial cells in vitro.

@article{Dorey1990EvidenceOM,
  title={Evidence of melanogenesis in porcine retinal pigment epithelial cells in vitro.},
  author={Cari Dorey and Xavier Torres and Theuns J P Swart},
  journal={Experimental eye research},
  year={1990},
  volume={50 1},
  pages={1-10}
}
Several weeks after porcine retinal pigment epithelial (RPE) cell cultures attain confluence, macroscopically visible brown foci appear. The cuboidal cells that form the foci contain numerous phase dark granules that do not exhibit the autofluorescence characteristic of lipofuscin. The data described here indicate that the granules are melanosomes. Electron microscopy revealed three types of electron-dense granules in these cells: simple spheres 0.3-0.5 microns in diameter, large spheres 1-2… CONTINUE READING
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