Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol.

@article{Hallman1982EvidenceOL,
  title={Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol.},
  author={Mikko Hallman and Roger G. Spragg and James H. Harrell and Kenneth M. Moser and Louis Gluck},
  journal={The Journal of clinical investigation},
  year={1982},
  volume={70 3},
  pages={
          673-83
        }
}
Autopsy findings suggest that lung surfactant is damaged in the adult respiratory distress syndrome. In the present study 225 bronchoalveolar lavage specimens (78 from 36 patients, 1-78 yr old with respiratory failure, 135 from another 128 patients with other respiratory disease, and 12 from healthy controls) were assayed for the lung profile [lecithin/sphingomyelin (L/S) ratio, saturated lecithin, phosphatidylinositol, and phosphatidylglycerol]. Bronchoalveolar lavage fluid was further… Expand
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Severe viral bronchiolitis is associated with an absence of surfactant activity and PG, which resolves by clinical recovery, andSurfactant administration is likely to be beneficial, but requires a selective approach. Expand
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Exogenous surfactant in acute respiratory distress syndrome: more is better
  • A. Anzueto
  • Medicine
  • European Respiratory Journal
  • 2002
TLDR
It is now known that surfactant dysfunction plays a major role in the pathophysiology of ARDS 6, 10, and functional changes have been described not only in patients with established ARDS, but also in patients at risk 10–12. Expand
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